You guys can only use pick on red crystals (during stage 1). If they are blue its because quest is at stage 2 or then stage 3.
How to check which stage quest is?
1) If there is a wall [this one] quest is at stage 1:
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2) If you can't go up the stairs [these stairs] quest is at stage 2.:
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3) If you can go up the stairs on the image above quest is at stage 3.