if you are running in compatibility mode, try without it, update your .net framework, if you are using MySQL make sure the settings are set properly for both the mysql server and the ot servers connection to the mysql server, if you are using SQLite, switch to MySQL and see if it makes a difference, also, you did not answer the question of weather or not other programs hang and stop responding?
in your bios check and see if hardware virtualization is on, for some reason by default in some pcs these things are disabled when having it disabled decreases performance and limits the capabilities of processing.
if you are not running as administrator try doing so, if you are running as administrator try running it without it
run a disk check be sure that your not running on bad sectors.
Post your results here.