you can move and cast spells/heal, but not at the same time, so you have to alternate between them, or if you want to move + heal you have to let go of ur mouse, which means you cant open doors etc.Maybe I'm kind of superhuman, but even moment ago when I was hunting I could manage to move, use GFB, loot monsters, target monsters and heal at same time.
clicking hotkeys AND arrowkeys are the same time isnt really possible to do with accuracy
if you claim to be able to do this id love to see how your hand is positioned to do it several hours a day